Description
Indications
Vitamin D3 insufficiency can be treated and prevented with colecalciferol (Vitamin D3). In patients with vitamin D3 deficiency, it can also be used as a supplement to particular osteoporosis treatment.
Pharmacology
Aristo D3 40000 aids in calcium and phosphorus absorption and reabsorption. Vitamin D3 is required for optimal bone growth and density maintenance. It also helps type 2 diabetes patients maintain optimal insulin levels by reducing the severity of bacterial infection, improving lung function, reducing the risk of cancer (breast, colorectal), and preventing cancer (breast, colorectal).
Dosage and Administration
For capsule: Adults:
Treatment of Vitamin D3 deficiency: 40000 IU once weekly for 7 weeks. Doses for maintenance therapy are 1400-2000 IU/day. To confirm the target level of 25 hydroxyvitamin D, measurement of it should be determined 3-4 months after initiating the maintenance therapy.
Prevention of Vitamin D3 deficiency: 20000 IU every 4 weeks. Higher doses may be required in certain situations.
Addition to specific therapy for osteoporosis: 20000 IU once a month.
For capsule: Children (12-18 years):
Treatment of Vitamin D3 deficiency: 20000 IU once every 2 weeks for 6 weeks.
Prevention of Vitamin D3 deficiency: 20000 IU every 6 weeks.
For film-coated tablets: 1000 IU (1-2 tablets) daily, or as directed by a physician. Take the medicine with food or within 1 hour after a meal.
For oroflash or chewable tablets: 1000 IU to 2000 IU daily, or as directed by a physician. Take the medicine with food or within 1 hour after a meal. Place the tablet in the mouth swallow after chewing.
For Syrup:
For patients with risk of Cholecalciferol deficiency:
0-1 yr: 400 IU/ day (2 ml)
>1 Yr: 600 lU/ day (3 ml)
For Cholecalciferol deficient patients:
0-1 yr: 2000 IU/ day (+50000 IU/week ) for 6 weeks
1 -18 yrs: 2000 IU/ day for 6 weeks.
Injection: Prevention:
Infants receiving Vitamin D enriched milk: 1/2 ampoule (0.5ml) i.e. 1,00000 I.U. every 6 months.
Nursed infants or infants not receiving Vitamin D enriched milk or young children up to 5 years of age: 1 ampoule (1ml) i.e. 2,00000 I.U. every 6 months.
Adolescents: 1 ampoule (1ml) i.e. 2,00000 I.U. every 6 months during winter.
Pregnancy: 1/2 ampoule (0.5ml) i.e. 1,00000 I.U. from the 6th or 7th month of pregnancy.
Elderly: 1/2 ampoule (0.5ml) i.e. 1,00000 I.U. every 3 months. Digestive disorders, concomitant treatment with antiepileptics & other particular condition not described above; 1/2 ampoule (0.5ml) i.e. 1,00000 I.U. or 1 ampoule (1ml) i.e. 2,00000 I.U. every 3 or 6 months.
Injection: Vitamin D deficiency:
1 ampoule (1ml) i.e. 2,00000 I.U. which can be repeated 1 to 6 months later. Or, as directed by the registered physician.
Interaction
Phenytoin, barbiturates, glucocorticoids, certain laxatives (such as liquid paraffin), actinomycin, and imidazole antifungal medicines are all affected.
Contraindications
It is contraindicated in patients with known hypersensitivity to Vitamin D3.
Side Effects
The general side effects are hypercalcaemia, hypercalciuria, skin rash, pruritus, urticaria, nausea, abdominal pain.
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