Description
Indications
Econazole Nitrate & Triamcinolone Acetonide indicated for the treatment of:
- Eczematous Mycoses
- Psoriasis
- Tinea Pedis (Athlete’s foot)
- Tinea Corporis (Ring worm)
- Tinea Cruris (Jock itch)
- Inflammatory Intertrigo
- Diaper Dermatitis
Onychomycoses- for the treatment of onychomycoses, local therapy with Econazole/Triamcinolone cream, combined with an oral antimycotic, is recommended.
Pharmacology
Econazole Nitrate: Econazole modifies the permeability of cell wall membrane in fungi; may interfere with RNA and protein synthesis, and lipid metabolism.
Triamcinolone has mainly glucocorticoid activity. It suppresses the migration of polymorphonuclear leukocytes and reduces capillary permeability thereby decreasing inflammation.
Dosage & Administration
Adults: This cream should be applied sparingly to the skin lesion no more than 2 times daily, preferably once in the morning and once in the evening. This cream should not be applied with an occlusive dressing, or to large areas of skin on the body. The duration of treatment with this cream should continue until the inflammatory symptoms subside but not longer than 2 weeks; after 2 weeks of therapy with this cream, continue therapy as needed with a preparation containing econazole or econazole nitrate alone.
Pediatric Use: Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing’s syndrome than mature patients because of a larger skin surface area to body weight. Caution should be exercised.
Interaction
Econazole is an oral anticoagulant that is metabolized by the CYP3A4/2C9 enzyme (warfarin & acenocoumarol).
Triamcinolone reduces the amount of salicylates in the blood. NSAIDs increase the risk of Gl bleeding and ulceration. Antagonized the antidiabetic’s blood glucose-lowering effects. Amphotericin B, beta-blockers, potassium-depleting diuretics, and theophylline all increase the risk of hyperkalemia. With ciclosporin, carbamazepine, phenytoin, barbiturate, and rifampicin, triamcinolone clearance is increased.
Contraindications
This Cream is contraindicated-
- In people who have exhibited hypersensitivity to one or more of the components.
- This Cream, like any other corticosteroid-containing dermatological preparation, is contraindicated in certain skin disorders, such as tuberculosis, varicella, herpes simplex, or other viral skin infections, or fresh vaccination sites.
- Ulcers of the Decubitus: Infections of the skin caused by viruses, bacteria, or fungi (e.g. tuberculosis of the skin, syphilis of the skin, herpes simplex, herpes zoster, chickenpox).
- Rosacea and rosacea-like dermatitis are two types of rosacea.
Side Effects
Transient local mild discomfort, itching, and redness may occur following application on a rare occasion. Econazole has a low allergenicity and is well tolerated by even sensitive skin. Adrenal suppression can occur while using long-term continuous topical steroid therapy, especially in infants and toddlers, or when using occlusive dressings. It’s important to keep in mind that an infant’s napkin can serve as an occlusive dressing.
Pregnancy & Lactation
Pregnancy: The Triamcinolone Acetonide, not the Econazole, enters the placenta, therefore topical corticosteroids during pregnancy can induce foetal development defects. The applicability of this discovery to humans has yet to be determined. Topical steroids in big doses or for lengthy periods of time should not be used during pregnancy.
Lactation: A tiny amount of econazole and, to a lesser extent, Triamcinolone is secreted in breast milk. As a result, this cream should not be given to a breastfeeding woman, or if it is, lactation should be stopped during therapy.
Precautions & Warnings
- For external use only. This Cream is not for ophthalmic or oral use.
- If a reaction suggesting hypersensitivity or chemical irritation should occur, use of the medication should be discontinued.
- Corticosteroids applied to the skin can be absorbed in sufficient amounts to produce systemic effects, including adrenal suppression. Systemic absorption may be increased by various factors such as application over a large skin surface area, application to damaged skin, application under occlusive skin dressings and prolonged duration of therapy.
- Topical corticosteroids are associated with skin thinning and atrophy, striae, telangiectasis and purpura.
- Topical corticosteroids may lead to increased risk of dermatological superinfection or opportunistic infection.
Children: Increased caution is required when treating children. Compared to adults, the nature of a child’s skin and the larger skin surface area relative to body weight may lead to an increased absorption of the corticosteroid via the child’s skin. This cream should be used in children only for short periods of time (less than 2 weeks) and on small areas (less than 10% of body surface area).
Visual disturbance may be associated with systemic and topical corticosteroid use. If a patient presents with symptoms such as blurred vision or other visual disturbances, the patient should be considered for referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma or rare diseases such as central serous chorioretinopathy (CSCR).
Therapeutic Class
Triamcinolone & Combined preparations
Storage Conditions
Store in a cool (below 30°C) and dry place, away from light. Keep out of the reach of children.
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