Description
Indications
As a dietary supplement, take:
- Vitamin E deficiency resulting from impaired absorption
- Increased requirements due to diet rich in polyunsaturated fats
- For healthy hair & skin
- As an antioxidant
- Hemolytic anemia due to Vitamin E deficiency
Application in medicine:
- Cardiovascular disease
- Heavy metal poisoning
- Hepatotoxin poisoning
- Hemolytic anemia
- Oxygen therapy
- In nutritional deficiency states.
Pharmacology
In the body, vitamin E functions as an antioxidant. Polyunsaturated fatty acids (components of cellular membranes) and other oxygen-sensitive compounds, such as vitamins A and C, are protected against oxidation by vitamin E. Vitamin E insufficiency can induce irritability, edema, thrombosis, and hemolytic anemia in preterm newborns. Adults and children with low serum tocopherol concentrations have been found to have creatinuria, ceroid deposition, muscular weakness, reduced erythrocyte survival, or enhanced in vitro hemolysis by oxidizing agents.
Dosage & Administration
Betterment of cardiovascular health: 400 IU-800 IU per day
Deficiency syndrome in adults: 200 IU-400 IU per day
Deficiency syndrome in children: 200 IU per day
Thalassemia: 800 IU per day
Sickle-cell anemia: 400 IU per day
Betterment of skin & hair: 200 IU-400 IU per day (Topical use is also established for beautification)
Chronic cold in adults: 200 IU per day
Interaction
Vitamin E may decrease vitamin A absorption and function, as well as increase the impact of warfarin.
Contraindications
There are no recognized contraindications.
Side Effects
Overdosage (more than 1 gm) has been linked to mild adverse effects such as hypertension, tiredness, diarrhea, and myopathy.
Pregnancy & Lactation
When taken in the appropriate dosage, vitamin E is safe to take throughout pregnancy and breastfeeding. Higher dosages have yet to be established.
Precautions & Warnings
In some people, such as those using estrogen, it may increase the risk of thrombosis.
Therapeutic Class
Herbal and nutraceutical preparations, as well as vitamin E preparations
Storage Conditions
Keep away from light and heat in a dry area. Keep out of children’s reach.
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